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Updated: Jan 13, 2026

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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BRCA2缺乏和复制压力驱动APOBEC3-介导的基因组不稳定性

Kathy Situ1,2, Haohui Duan1,2, Stephen K Godin1,2

  • 1Center for Personalized Cancer Therapy, University of Massachusetts Boston, Boston, MA, USA.

Nature communications
|October 30, 2025
PubMed
概括

BRCA2 缺乏导致DNA 中 uracil 积累,导致基因组不稳定. 丁脱氨酶APOBEC3B驱动这个过程,创建一个自我强化的循环,使BRCA2突变癌症的结果恶化.

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