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综合多学科探讨了在改变饮食过程中代谢通路流动中的微生物功能

Yiming Zhao^1,2, Siqi Yao¹, Abdulrahim Umar¹

¹Human Microbiome and Health Group, Department of Microbiology, Xiangya School of Basic Medical Science, Central South University, Changsha, Hunan, China.

NPJ science of food

|October 30, 2025

概括

从高蛋白饮食转换为高纤维饮食可以增强肠道微生物的多样性,并改变新陈代谢途径,特别是涉及托和糖的新陈代谢途径. 像Faecalibacterium rodentium和Akkermansia muciniphila这样的特定细菌起着关键的作用. 这凸显了食纤维对肠道健康的重要性.

科学领域:

微生物学微生物学
代谢学代谢学代谢学
营养科学营养科学

背景情况:

饮食转变,例如从高蛋白饮食 (HPD) 过渡到高纤维饮食 (HFiD),对于健康管理来说是常见的.
肠道微生物组在饮食和宿主健康之间起着至关重要的调解作用.
有限的研究已经探索了饮食变化对肠道微生物组成和代谢景观的综合影响.

研究的目的:

调查从HPD切换到HFiD对肠道微生物组结构和功能的影响.
通过多omics方法来表征相关的代谢概况变化.
为了确定由这种饮食过渡影响的关键微生物和代谢因素.

主要方法:

利用了多种omics技术,包括16S rRNA基因测序,射门元基因组学和LC-MS/MS代谢学.
应用机器学习方法来分析肠道微生物群的反应,并关联微生物和代谢变量.
检查了肠道微生物群多样性和代谢通路活性的变化.

主要成果:

从HPD转换为HFiD显著改善了肠道微生物的多样性.
观察到与托,银河糖,果糖和曼代谢相关的代谢途径的丰富.
确定了包括Faecalibacterium rodentium和Akkermansia muciniphila在内的特定微生物物种,可能与这些代谢转变有关.

结论:

从HPD到HFiD的饮食过渡对肠道微生物多样性和关键代谢途径产生积极影响.
特定的肠道细菌可能在调解高纤维饮食的代谢适应方面发挥关键作用.
这些发现为进一步研究饮食-微生物-代谢物相互作用提供了基础,并强调了饮食多样性的重要性.

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