疼痛灾难化及其领域显著影响类风湿性关节炎疾病活动
Damiano Currado1,2, Lyubomyra Kun2, Francesca Saracino2
1Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Scientific reports
|October 30, 2025
概括
疼痛灾难化显著恶化类风湿性关节炎 (RA) 疾病活动,特别是化和无助的领域. 解决这些认知因素对于改善RA患者的治疗结果至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 疼痛心理学 疼痛心理学
- 临床医学 临床医学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,其特点是关节炎症和疼痛.
- 疼痛灾难化 (PC),一种对疼痛的负面认知情感反应,在慢性疼痛疾病中很普遍.
- PC对RA疾病活动的影响及其与焦虑和抑郁症的关系需要进一步研究.
研究的目的:
- 评估疼痛灾难化 (PC) 对类风湿性关节炎 (RA) 患者疾病活性的影响.
- 探索PC和RA疾病活动之间的关联是否受到焦虑和抑郁的影响.
主要方法:
- 一项多中心的观察性研究,涉及158名RA患者.
- 使用CDAI,SDAI和DAS28-CRP.评估疾病活动.
- 使用疼痛灾难化尺度 (PCS) 评估PC,包括无助,反和放大领域.
- 统计分析包括单变量和多变量回归.
主要成果:
- 较高的PCS得分与增加的RA疾病活性显著相关 (CDAI,SDAI,DAS28-CRP).
- PC的Rumination和Helplessness领域与疾病活动有很强的相关性,而放大却没有.
- 这些关联仍然显著,独立于焦虑和抑郁水平.
结论:
- 疼痛灾难化,特别是化和无助感,显著影响RA疾病的活动.
- 这些认知因素影响RA疾病活动,独立于情绪障碍,如焦虑和抑郁.
- 针对不适应性疼痛感知对于改善RA管理和患者的治疗结果至关重要.
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