活动和非惰性拥挤对自行式标记粒子动态的竞争效应
Baburao Simma1, Vrinda Garg1, Radha Ramana1
1Department of Physics, National Institute of Technology, Warangal, 506004, India.
Scientific reports
|October 30, 2025
概括
自行粒子克服拥挤效应,在复杂的环境中显示增强的扩散. 积极的推进恢复了运动秩序,与被动的追踪器不同,这些追踪器会陷入困境.
科学领域:
- 物理 物理学 物理
- 生物物理学的生物物理.
- 软物质物理学 软物质物理学
背景情况:
- 分子运输对于生物功能至关重要.
- 拥挤的环境显著影响粒子动态.
研究的目的:
- 在有序,拥挤的环境中研究痕迹粒子动态.
- 分析 crowder 粘性和包装分数对扩散的影响.
主要方法:
- 低压兰格温动力学模拟.
- 模拟高阻尼率和有吸引力的中心的人群.
- 分析被动和自动推进的追踪器扩散.
主要成果:
- 被动标记物显示亚扩散;活动标记物显示超扩散.
- 拥挤抑制了中间分数的扩散,但积极的推进增强了移动性.
- 吸引力的潜在重叠在极端拥挤增加扩散.
- 推进恢复了被粘性子破坏的ergodicity.
结论:
- 积极推进是克服拥挤的生物系统中运输限制的关键.
- 标志物行为 (亚扩散与超扩散) 取决于推进和拥挤特征.
- 了解这些动态对于细胞过程和药物输送至关重要.
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