循环中的CD24/Siglec-10生物标志物预测心脏骤停队列中复苏后的结果
Ying Liu1, Yushu Chen1,2, Ling Wang3
1Department of Emergency Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Scientific reports
|October 30, 2025
概括
血清可溶性CD24 (sCD24) 水平预测了心脏骤停幸存者的神经学结果和死亡率不佳. 升高的sCD24和其他生物标志物表明自发循环 (ROSC) 恢复后的预后更差.
科学领域:
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
- 生物标志物发现发现
背景情况:
- CD24/Siglec-10轴在组织损伤后的免疫抑制中发挥作用.
- 了解与心脏骤停结果相关的生物标志物对于患者管理至关重要.
研究的目的:
- 在CD24/Siglec-10轴内调查血清生物标志物.
- 探索这些生物标志物与心脏骤停 (CA) 和自发循环恢复 (ROSC) 后的生存/神经预后之间的关联.
主要方法:
- 在ROSC后对104名患者进行前性队列研究.
- 在ROSC后的1,3和7天收集sCD24,sSiglec-10,酸,TNF-α,IL-6,HMGB1,NSE和神经氨基酶活性的血清水平.
- 评估了28天的生存期和神经结果.
主要成果:
- 与幸存者相比,非幸存者表现出大多数生物标志物的水平明显更高.
- 血清sCD24与炎症标志物 (TNF-α,IL-6),HMGB1,NSE,酸和神经氨基酶活性正相关.
- 血清sCD24的升高独立地与28天的神经预后和死亡率不佳有关.
结论:
- 血清生物标志物,特别是sCD24,在ROSC后显著升高.
- 升高的sCD24是心脏骤停患者神经预后和死亡率不佳的潜在预测因素.
- 需要进一步的大规模研究来验证这些发现.
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