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Updated: Jan 13, 2026

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
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翻译框架将 perfluoroheptanoic acid (PFHpA) 暴露与青少年的代谢功能障碍相关的脂肪性肝病联系起来

Brittney O Baumert1, Ana C Maretti-Mira2, Douglas I Walker3

  • 1Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. bbaumert@usc.edu.

Communications medicine
|October 30, 2025
PubMed
概括

透和多醇基物质 (PFAS),特别是 perfluoroheptanoic 酸 (PFHpA),与青少年的代谢功能障碍相关的脂肪性肝病 (MASLD) 风险增加有关. 蛋白质失调在MASLD发展中起着关键作用,建议新的治疗点.

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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