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Updated: Jan 13, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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Published on: November 28, 2019

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癌症抑制了巨细胞中的线粒体伴侣活动,以驱动免疫逃避

Haoxin Zhao1,2, Jaeoh Park3,4, Yuzhu Wang5,6

  • 1Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH, USA.

Nature immunology
|October 30, 2025
PubMed
概括

瘤相关巨细胞 (TAMs) 使用TRAP1 (TNF受体相关蛋白-1) 来限制它们的抑制功能. 恢复TRAP1重新编程TAMs,增强抗瘤免疫力并破坏瘤微环境中的免疫逃避.

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