在H. pylori感染中探索肠道微生物群的组成和预测功能变化
Noha Salah Soliman1, May Sherif Soliman2, Heba Sherif Abdel Aziz2
1Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt. noha.salah@kasralainy.edu.eg.
Scientific reports
|October 30, 2025
概括
杆菌感染会改变肠道微生物群的组成和功能. 肠道微生物组的这些变化可能会导致与H. pylori相关的炎症和癌症风险.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 人类微生物组研究研究
背景情况:
- 杆菌 (H. pylori) 感染是一个全球性的健康问题,已知有胃肠道影响.
- 虽然H. pylori会影响胃微生物群,但它对肠道微生物群组成和功能的影响不太清楚.
- 肠道微生物群的功能作用至关重要,但在H. pylori感染的背景下仍未得到充分研究.
研究的目的:
- 研究与H. pylori感染相关的肠道微生物群的组成和功能转变.
- 为了比较H. pylori感染个体的肠道微生物组与对照组.
主要方法:
- 从54名参与者收集了便样本 (31名H. pylori感染者,23名对照者).
- 在所有样本上进行了16S rRNA下一代测序.
- 生物信息分析被用来评估微生物的组成和功能途径.
主要成果:
- 阳性H. pylori个体显示出更高的Bacteroidetes和Proteobacteria类的相对丰度,以及Bacteroides和Prevotella属.
- 特定的物种,如Bacteroides vulgatus和大肠杆菌在H. pylori阳性组中更为丰富.
- 在 H. pylori 阳性个体中观察到,MAPK 信号传递,细胞循环,氨酸和氨酸通路的丰度增加.
结论:
- 甲状腺菌感染与肠道微生物群的显著组成和功能变化有关.
- 这些微生物组的变化可能在与H. pylori相关的肠道炎症中发挥作用.
- 鉴定到的转变表明,可能与H. pylori感染中的恶性转变有关.
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