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提尔法能重编程神经元,促进脊髓损伤后的功能恢复

E A van Niekerk1, C Marques de Freria2, B O Mancarci3

  • 1Department of Neurosciences, University of California San Diego, La Jolla, CA, USA. evanniekerk@health.ucsd.edu.

Nature
|October 30, 2025
PubMed
概括

No abstract available in PubMed .

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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