Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Polygenic Traits01:18

Polygenic Traits

68.8K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
68.8K
Prediction Intervals01:03

Prediction Intervals

3.2K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
3.2K
End Point Prediction: Gran Plot01:07

End Point Prediction: Gran Plot

1.1K
A Gran plot is used to predict the equivalence volume or endpoint of a potentiometric or acid-base titration without reaching the endpoint. Typically, titration data is collected as a function of the titrant's volume up to a point less than the equivalence volume and then transformed into a linear format. The straight line is extended to the x-axis, indicating the necessary titrant volume to achieve the equivalence point.
For potentiometric titration, the Gran plot is created by plotting...
1.1K
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

238
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
238
Improving Translational Accuracy02:07

Improving Translational Accuracy

14.1K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
14.1K
Improving Translational Accuracy02:07

Improving Translational Accuracy

3.5K
3.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Precision Functional Parcellation of the Human Cortex via Rest-Task fMRI Fusion.

bioRxiv : the preprint server for biology·2026
Same author

Association of Genetic Liability to Psychiatric Disorders with Peripheral Metabolic Dysregulation.

medRxiv : the preprint server for health sciences·2026
Same author

Rare Coding Variants Reveal Distinct Genetic Architectures Across Multidimensional Sleep Phenotypes.

medRxiv : the preprint server for health sciences·2026
Same author

Adaptive transfer learning for time-to-event modeling with applications in disease risk assessment.

Biostatistics (Oxford, England)·2026
Same author

Exome sequencing directly implicates 68 genes in inflammatory bowel disease.

medRxiv : the preprint server for health sciences·2026
Same author

Regional heterogeneity in phenotypic and genetic associations between bone and brain in humans.

Nature communications·2026
Same journal

Near-perfect genome sequencing in medical genetics.

Nature genetics·2026
Same journal

Three decades of cancer genetics.

Nature genetics·2026
Same journal

Advances and challenges of splicing prediction with AI.

Nature genetics·2026
Same journal

Non-coding variant prioritization based on cell type, developmental stage and evolutionary constraint.

Nature genetics·2026
Same journal

Co-expression-based models improve eQTL predictions for transcriptome-wide association studies and highlight new schizophrenia-associated genes.

Nature genetics·2026
Same journal

Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.

Nature genetics·2026
查看所有相关文章

相关实验视频

Updated: Jan 13, 2026

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.4K

实时动态多基因预测,用于数据流.

Justin D Tubbs1,2,3, Yu Chen3,4,5, Rui Duan2,6

  • 1Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

Nature genetics
|October 30, 2025
PubMed
概括
此摘要是机器生成的。

实时PRS-CS使用连续数据流动地提炼多基因风险评分 (PRS),提高精准医学的预测准确性. 这种新的方法通过随着时间的推移适应新的遗传和健康信息,提高了PRS在临床环境中的实用性.

更多相关视频

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.5K
Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

1.2K

相关实验视频

Last Updated: Jan 13, 2026

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.4K
Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.5K
Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

1.2K

科学领域:

  • 遗传学 是一个遗传学.
  • 生物信息学是一种生物信息学.
  • 精准医学是一门精准的医学.

背景情况:

  • 多基因风险评分 (PRS) 对精准医学至关重要,但依赖于过时的全基因组关联研究 (GWAS) 数据.
  • 目前的PRS方法是静态的,随着新数据的出现,限制了它们对入院患者的预测准确性.
  • 需要动态的PRS构建,集成不断生成的遗传和健康结果数据.

研究的目的:

  • 引入实时PRS-CS (rtPRS-CS),一种用于在线,动态改进PRSs的新方法.
  • 评估rtPRS-CS在使用流数据提高PRS预测准确性的性能.
  • 为了证明rtPRS-CS在不同人群中的临床实用性以及疾病风险预测.

主要方法:

  • 开发了rtPRS-CS,用于在线,动态的PRS构建和标准化,每次新样本.
  • 进行了广泛的模拟,以评估各种遗传架构和样本大小的rtPRS-CS性能.
  • 将rtPRS-CS应用于两个大型生物库和亚洲地区22个精神分裂症队列的定量特征.

主要成果:

  • rtPRS-CS有效地集成了大量的流数据,以随着时间的推移提高PRS预测的准确性.
  • 模拟证实了rtPRS-CS在不同基因架构和训练样本大小的稳定性.
  • 证明rtPRS-CS在动态捕捉健康状况变化和预测不同祖先疾病风险方面的临床实用性.

结论:

  • rtPRS-CS通过实现实时适应,比静态PRS方法提供了显著的进步.
  • rtPRS-CS的动态性质增强了准确医学应用的预测能力.
  • rtPRS-CS显示了改善疾病风险预测和不同人群的临床管理的前景.