多胎妊娠与周产期心肌病之间的关联:系统性审查和元分析
Triwedya Indra Dewi1, Azizah Muthiah2, Chaerul Achmad2
1Department of Cardiology and Vascular Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia. triwedya.indra.dewi@unpad.ac.id.
BMC cardiovascular disorders
|October 30, 2025
概括
多胎妊娠显著增加了周周心肌病 (PPCM) 的风险. 由于这种风险增加,医疗保健提供者应对多胎孕妇女进行PCM查.
科学领域:
- 心脏病学 心脏病学
- 产科 产科 产科 产科 产科
- 生殖健康 生殖健康
背景情况:
- 产前心肌病 (PPCM) 诊断已经确立,但其致病性和与多胎妊娠的联系仍然不清楚.
- 之前没有任何元分析专门研究过多胎妊娠与PPCM风险之间的关联.
- 这项研究解决了关于多胎妊娠作为PPCM风险因素的知识差距.
研究的目的:
- 评估多胎妊娠与周产期心肌病 (PPCM) 的发展之间的关联.
- 提供PPCM风险在多胎孕妇女的定量评估.
主要方法:
- 在PubMed,Scopus和ScienceDirect进行了全面的文献搜索,截至2025年5月.
- 包括的研究调查了多胎妊娠和PPCM概率之间的联系.
- 通过Mantle-Haenszel方法分析数据,使用随机效应模型与合并的赔率比率 (ORs).
主要成果:
- 该元分析包括11项前性和后性观察性研究,涉及8个国家的1150多万参与者.
- 多重怀孕与患PPCM的风险增加有显著的关联.
- 合并的几率比为2.59 (95% CI:2.17-3.10),表明风险增加了两倍以上 (P < 0.00001).
结论:
- 多胎妊娠与PPCM的风险明显增加有关.
- 针对性查PPCM建议女性经历多胎妊娠,因为他们的高风险状态.
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