在2型糖尿病患者中,25-基维生素D水平和残留胆固醇之间的相关性
Luyan Zhang1,2, Liyuan Gao2, Yiqiong Shi2
1The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu Province, 730000, China.
BMC endocrine disorders
|October 30, 2025
概括
在2型糖尿病患者中,维生素D水平与残留胆固醇存在复杂的非线性联系. 年龄显著改变了这种关系,表明需要个性化维生素D干预来管理心血管风险.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 营养科学 营养科学
背景情况:
- 剩余胆固醇 (RC) 是2型糖尿病 (T2DM) 的一个关键心血管风险因素.
- 维生素D缺乏与T2DM发展有关,但其与已建立的T2DM中RC的关联不清楚.
- 潜在的非线性效应和年龄/性别变化需要进行研究.
研究的目的:
- 在T2DM患者中研究血清25-基维生素D (25(OH) D) 和RC之间的关系.
- 探索非线性关联和值效应.
- 为了确定年龄和性别是否会改变25(OH) D-RC关系.
主要方法:
- 对380名T2DM患者 (283名男性,97名女性) 的分析.
- 人口统计数据的描述性分析.
- 细分线性回归以确定值效应并评估25(OH) D和RC之间的关联.
主要成果:
- 女性性别与较高的RC水平相关 (ρ=0.163,p=0.002).
- 确定了在18.8 ng/mL的25(OH) D的值效应.
- 在18.8 ng/mL以下,增加25(OH) D降低了RC;在此以上,增加25(OH) D提高了RC. 年龄显著改变了这种关联 (相互作用p<0.05).
结论:
- 在T2DM中,25(OH) D和RC之间存在复杂的非线性关系.
- 年龄显著改变了维生素D对RC的影响.
- 基于维生素D状态的量身定制干预措施可能有利于在T2DM中管理RC.
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