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作为COX抑制剂的trifluoromethyl-pyrazole-carboxamides:合成,微型结构分析,计算分析和生物评估

Mohammed Hawash1, Nisreen Shweiki2, Mohammed T Qaoud3

  • 1Department of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine. mohawash@najah.edu.

BMC chemistry
|October 30, 2025
PubMed
概括

新的trifluoromethyl-pyrazole-carboxamide衍生物显示出强大的抗炎活性,具有选择性的COX-2抑制. 一些化合物还表现出抗癌潜力和有利的药理动力学特性,需要进一步的临床研究.

关键词:
抗炎药物是一种抗炎药物.科克斯 (COX) 是一个细胞毒性 细胞毒性这是一个微型ED.无抗炎药 (NSAIDs) 是一种无抗炎药.三甲基 - - 皮拉醇三.

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