陶氏脱氧胆酸通过调节胆酸代谢和肉肠道微生物群之间的交叉关系来促进腹部脂肪沉积
Xi Sun1, Chaohui Wang1, Xiaoying Liu1
1College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Journal of animal science and biotechnology
|October 30, 2025
概括
通过激活胆汁酸受体,陶氏脱氧胆酸 (TCDCA) 的使用增加了 brojlers 的腹部脂肪. 这种干预还改变了肠道微生物群和胆酸概况,影响了脂质代谢.
科学领域:
- 动物科学动物科学
- 代谢研究研究 代谢研究
- 微生物组研究 微生物组研究
背景情况:
- 胆汁酸,如陶罗二氧化醇酸 (TCDCA),在宿主新陈代谢和肠道微生物群调节中起着至关重要的作用.
- TCDCA是中占主导地位的胆汁酸,与代谢障碍有关.
- 了解TCDCA对肉腹部脂肪沉积的影响对于代谢健康很重要.
研究的目的:
- 研究TCDCA口服对肉腹部脂肪沉积的影响.
- 探索潜在的机制,包括对基因表达,血清代谢物和肠道微生物组合的影响.
主要方法:
- 肉从14天到28天的年龄内口服了TCDCA (0.05g,0.10g,0.20g) 或盐水的不同剂量.
- 测量包括体重,料摄入量,腹部脂肪百分比,血清代谢物,腹部脂肪中的基因表达,以及部微生物群分析 (16S rRNA测序).
主要成果:
- 服用TCDCA (0.20g) 显著增加了腹部脂肪百分比,血清TBA和HDL-c水平,并倾向于增加甘油三水平.
- 在腹部脂肪中观察到脂质基因 (SREBP-1,C/EBP-α,ELOVL6) 的上调和脂肪酸氧化基因 (ATGL,CPT-1) 的下调.
- TCDCA改变了胆汁酸概况,增加了肝胆汁酸合成和运输基因表达,并在腹部脂肪中调高了FXR,VDR和FGF19.
- 对Cecal微生物群的分析显示,多样性减少 (Shannon,Simpson指数) 和Firmicutes/Bacteroidetes比率增加,主要细菌属的转变和脂肪代谢途径的增强.
结论:
- 在肉中,TCDCA干预 (0.20g) 促进了腹部脂肪沉积.
- 这种效应通过激活腹部脂肪中的胆酸受体来调节,导致脂质代谢发生改变.
- 肠道微生物群落和胆酸特征的同时变化有助于观察到的代谢效应.
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