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时机是一切:一种简单的化学方法来确定杀虫剂的生物可用表面度,用于杀虫剂处理的净评价

Ole Skovmand¹, Duoc M Dang², Trung Q Tran^2,3

¹MCC47-Consulting Vector Control, Castelnau Le Lez, France.

Malaria journal

|October 30, 2025

概括

确定杀虫剂处理网 (ITN) 洗间隔的新方法显示了更好的准确性. 与世界卫生组织 (WHO) 标准协议相比,冷酸方法 (CAM) 更好地预测ITN的性能.

科学领域:

医学昆虫学医学昆虫学
材料科学材料科学材料科学
分析化学分析化学

背景情况:

用杀虫剂处理的网 (ITNs) 需要世界卫生组织 (WHO) 根据20次洗后的生物有效性进行预资格.
洗间隔 (WI) 通过再生时间 (RT) 方法确定,这可能取决于应变.
不准确的WI可以导致产品过早失效或低估洗耐用性.

研究的目的:

评估化学方法,以确定在ITN中的deltamethrin和Piperonyl Butoxide (PBO) 表面度.
为了将化学测量与生物疗效相关联 (中位冲击时间,MKDT).
将新方法与世卫组织标准的再生时间 (RT) 方法进行比较,以确定洗间隔.

主要方法:

对比前后方法 (BAM),洗和分析方法 (SWAM) 和冷方法 (CAM) 进行AI量化.
使用SWAM或CAM估计的RT与使用易感和耐药蚊子与MKDT相关.
使用BAM和CAM评估的冲洗阻力指数 (WRI).

主要成果:

CAM剂量与MKDT有很强的相关性 (r = -0.91,p = 0.0006),样本间变化很小 (<2%).
通过化学方法 (CAM,SWAM) 获得的WI比标准WHO方法的WI更长.
电子显微镜证实了在线上化物的再结晶,减少了生物活性.

结论:

CAM提供可靠的RT估计,与生物疗效良好相关.
化学方法,特别是CAM,比WHO标准方法更好地预测ITN的性能.
结合MKDT和SWAM可以提高ITN性能预测;BAM适用于根据世卫组织协议测量AI损失.

关键词:

生物有效性生物有效性用杀虫剂处理的床网 (ITN)长期使用的杀虫网 (LLIN)平均停机时间 (MKDT)再生时间是再生时间.试验方法试验方法洗间隔的时间间隔.

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