相关实验视频

Updated: Jan 13, 2026

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

结肠中的性变态是由一个安德روج因-IL33+ stromal 细胞轴介导的

Haoyu Wang¹, Baowei Jing¹, Juan Zou¹

¹Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430072, China.

Cell & bioscience

|October 30, 2025

概括

结肠是一个关键的雄激素代谢枢纽. 在IL-33+ stromal细胞中的雄激素受体驱动着结肠健康和疾病的性别差异.

科学领域:

胃肠病学胃肠病学
内分泌学在内分泌学.
免疫学免疫学免疫学

背景情况:

在结肠病流行病学,进展和治疗结果方面存在显著的基于性别的差异.
结肠性二重体的基础上的分子机制尚未得到充分理解.

研究的目的:

为了研究雄激素和雄激素受体在结肠性变异中的作用.
确定推动结肠性别差异的细胞和分子机制.

主要方法:

在结肠中对雄激素代谢的分析.
在结肠中识别表达雄激素受体 (AR) 的细胞.
调查AR信号传递和凝结物形成,以应对性别偏差的雄激素水平.
转录分析,以识别AR调节的基因.

主要成果:

结肠作为一个关键的雄激素代谢中心,由性腺衍生的雄激素影响性别二态水平.
表达互白素-33 (IL-33) 的结肠层细胞是表达雄激素受体 (AR) 的主要群体.
性别偏差的雄激素水平促进AR核转位和液-液相分离的凝聚物组合在男性结肠层细胞中,调节像SerpinA3N和MT1.1.这样的基因.

结论:

在IL-33表达细胞中的雄激素受体信号传递为结肠中的性别差异提供了分子和细胞基础.
确定了涉及雄激素和IL-33+ stromal 细胞的性腺结肠轴,解释了结肠生理和疾病的性别差异.

关键词:

雄激素受体的受体雄激素受体结肠结肠结肠结肠不平等性不平等性戈纳德·戈纳德 (Gonad Gonad) 是一个性爱性的性爱性的性爱

更多相关视频

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells

Published on: January 22, 2021

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

相关概念视频

Renewal of Intestinal Stem Cells

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...