相关实验视频

Updated: Jan 12, 2026

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

针对微生物组衍生的外体来克服癌症治疗抵抗:机制,影响和机会

Vaibhav Singh¹, Ekta Shirbhate¹, Rakesh Kore¹

¹Department of Pharmacy, Guru Ghasidas University, Bilaspur-495 009, (C.G.), India.

Mini reviews in medicinal chemistry

|October 30, 2025

概括

来自微生物组的外体因子通过转移抵抗因子和改变细胞信号传递,与癌症治疗耐药性有关. 了解这些机制可能会导致新的治疗策略来克服耐药性并改善患者的生存率.

科学领域:

在瘤学瘤学.
微生物学微生物学
分子生物学分子生物学

背景情况:

癌症治疗耐药性是一个主要的临床挑战.
主体微生物组显著影响癌症的发展和治疗反应.
微生物组衍生的外体正在成为癌症生物学中的关键调解者.

研究的目的:

审查癌症治疗耐药性和微生物组衍生的外体细胞之间的复杂联系.
探索这些外生体介导抗性的机制.
讨论微生物组衍生外体作为治疗和诊断工具的潜力.

主要方法:

临床前和临床研究的文献综述.
对外体介导的水平基因转移和信号通路的分析.
研究特定的微生物物种及其与外体相关的耐药性机制.

主要成果:

来自微生物组的外基因组转移耐药性酶,并调高与耐药性相关的微RNA (miRNAs).
像Akkermansia muciniphila这样的特定细菌显示出改善免疫治疗结果的潜力.
来自Fusobacterium nucleatum的囊泡通过自激活促进了对氧沙的抗性.

结论:

来自微生物组的外体在调节癌症治疗耐药性方面发挥着至关重要的作用.
准这些外基因组为新的癌症疗法提供了一个有希望的途径.
需要进一步的研究和开发来克服临床应用的局限性.

关键词:

微生物组是一个微生物组.癌症癌症癌症癌症癌症外基因组是外基因组的组成部分.治疗耐药性治疗耐药性瘤的微环境.

更多相关视频

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Published on: September 19, 2025

相关概念视频

Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...