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含氨酸的芳香硫胺,具有对人类和真菌异型的碳酸无水酶抑制特性

Andrea Angeli1, Anthi Petrou2, Victor Kartsev3

  • 1Neuro Farba Department, Sezione di Scienze Farmaceutiche, Università degli Studi di Firenze, Florence, Italy.

Chemical biology & drug design
|October 30, 2025
PubMed
概括

库马林基硫胺酸对真菌碳酸无水酶 (CA) 具有强烈的抑制作用,其中一些化合物在对抗马拉西亚菌种的基准药物方面表现优于基准药物. 这项研究突出了潜在的治疗应用的新型CA抑制剂.

关键词:
碳酸无水酶是一种碳酸无水酶.停靠的对接方式这是一种真菌CACA.抑制抑制抑制的抑制作用硫胺酸硫胺的使用方法

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