在患有双侧静脉病变和持续的姿势感知头的患者中,空间定向障碍
Vivien Oertle1, Sandra Becker-Bense1, Thomas Brandt1,2
1German Center for Vertigo and Balance Disorders, LMU University Hospital, Munich, Germany.
Brain and behavior
|October 30, 2025
概括
患有持续的姿势感知性头 (PPPD) 和双边前庭病变 (BVP) 的患者经历了空间定向障碍. 这表明PPPD中前庭输入的中心抑制,即使前庭功能正常.
科学领域:
- 神经科学是一个神经科学.
- 垂体系统研究研究 垂体系统研究
- 临床心理学 临床心理学
背景情况:
- 双侧带病 (BVP) 和持续的姿势感知性头 (PPPD) 是导致步态失衡的慢性头状况.
- BVP涉及前体损失和空间失调,而PPPD呈现出正常的前体功能.
- 中央多感官错误整合与PPPD有关,促使研究其对空间定向的影响.
研究的目的:
- 调查PPPD是否尽管前庭功能正常,但影响空间定向能力.
- 为了比较PPPD患者的空间定向与BVP患者和健康对照 (HC).
主要方法:
- 一个临床床试验,三维现实世界指点任务 (3D-RWPT),被用来评估空间取向.
- 3D-RWPT结合了认知 (精神旋转) 和前体 (身体旋转) 的范式.
- 参与者填写了关于感知空间能力和与定位相关的不适的问卷.
主要成果:
- 与HC相比,BVP和PPPD患者在3D-RWPT中的准确性显著降低.
- 这种障碍在BVP和PPPD组中依赖于前庭功能的子任务中尤为明显.
- 虽然自我评估的空间能力在各组之间是可比的,但BVP和PPPD患者报告了更高水平的空间定向不适.
结论:
- 带有正常前庭功能的PPPD患者表现出空间定向受损.
- 这种缺陷可能表明前庭输入的中央抑制,可能是焦虑驱动的.
- 这种抑制会影响身体运动和相对于环境的位置的内部表现.
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