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Updated: Jan 12, 2026

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年龄对早期CAR T细胞治疗毒性的影响:一种倾向性得分匹配分析

Jia Yi Tan1, Yong-Hao Yeo2, Qi Xuan Ang3

  • 1Department of Internal Medicine, New York Medical College at Saint Michael's Medical Center, Newark, New Jersey, USA.

Cancer medicine
|October 30, 2025
PubMed
概括

对于老年人来说,CAR-T疗法是安全的,尽管他们患脏和心脏问题的比例较高. 建议对这些患者进行密切监测,以确保治疗的安全性和有效性.

关键词:
在CAR T疗法治疗中.仿制性抗原受体的仿制性抗原受体血液学 血液学 血液学瘤学 在瘤学方面.结果就是结果.

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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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