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Updated: Jan 12, 2026

Efficient Gene Knockdown in the Liver via Intrasplenic Injection of Adeno-Associated Virus Serotype 8 (AAV8)-Delivered Small Hairpin RNA
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基于重组AAV的肝向基因敲除小鼠模型的深入优化和系统评估.

Ying Zhu1,2,3, Guohua You4, Yong Jiang5

  • 1Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|October 30, 2025
PubMed
概括

一种新的,快速且具有成本效益的复合腺相关病毒 (rAAV) 工具使得小鼠的肝脏特异基因被淘汰. 这种优化的模型加速了临床前肝脏研究和治疗开发.

关键词:
库弗弗细胞是库弗弗细胞.肝脏内侧侧状内皮细胞是肝脏内侧侧状内皮细胞.肝脏特异性敲除作用鼠标模型 鼠标模型鼠标模型再组合腺相关病毒.

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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