对糖尿病外围神经病变的全面见解:病理生理学和治疗方法
Sumit Kumar1, Vandana Arora Sethi1, Chitra Gupta1
1Lloyd Institute of Management and Technology, Plot no. 11, Knowledge Park 2, Greater Noida, Uttar Pradesh, 201306 India.
糖尿病外围神经病变 (DPN) 的管理需要采取综合方法. 有效的治疗针对潜在的原因和症状,改善患者的生活质量.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病周围神经病变 (DPN) 是糖尿病的常见并发症,由长期高血糖引起.
- DPN导致神经病痛,感官丧失和生活质量下降.
研究的目的:
- 审查糖尿病外围神经病变的病理生理学和治疗策略.
- 总结目前对DPN的药理和非药理干预措施.
主要方法:
- 在PubMed,ScienceDirect,Scopus和Web of Science (2009-2025) 的综合文献搜索.
- 关键词包括"糖尿病外围神经病变"",病理生理学"",药物治疗"和"非药物治疗".
- 包括英语研究,不包括动物模型和其他糖尿病并发症.
主要成果:
- DPN的发病包括代谢和炎症变化,导致神经损伤和疼痛.
- 美国食品和药物管理局批准的DPN药物包括普雷加巴林,杜洛西丁, gabapentin, tapentadol,特拉马多尔和素8%补丁.
- 非FDA批准的非药物选择,如阿米特利普提林,利多卡因贴片,脊髓刺激,TENS,针和振动疗法显示出治疗潜力.
结论:
- 优化DPN患者的结果需要一个多方面的策略,结合药理和非药理疗法.
- 解决病理生理机制并提供症状缓解可以提高DPN患者的治疗疗效和生活质量.
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