系统性炎症反应指数轨迹与动脉动脉样硬化进展之间的关联
Ningning You1, Jing Su2, Yi Chen1
1Department of Gastroenterology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China.
Frontiers in endocrinology
|October 30, 2025
概括
系统性炎症反应指数 (SIRI) 与心血管疾病有关. 较高的初始SIRI和持续高的SIRI轨迹增加了动脉动脉样硬化进展的风险,有助于早期识别有针对性的干预措施.
科学领域:
- 心血管医学 心血管医学
- 炎症生物标志物 炎症生物标志物
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 系统性炎症反应指数 (SIRI) 是心血管疾病 (CVD) 的公认生物标志物.
- 目前尚不清楚SIRI轨迹与动脉样硬化 (CAS) 进展之间的关系.
研究的目的:
- 调查最初和长期SIRI水平与动脉动脉样硬化症 (CAS) 的进展之间的关联.
- 确定SIRI趋势是否可以预测成年人CAS进展.
主要方法:
- 这是一项11623名成年人进行的纵向回顾性队列研究,数据为2017年1月至2024年9月.
- 隐性类轨迹建模用于分析随时间推移的SIRI趋势.
- 考克斯的比例危险分析评估了与SIRI水平和轨迹相关的CAS进展风险.
主要成果:
- 一个1-SD增加的SIRI与12%更高的CAS进展风险相关 (HR=1.121).
- 高稳定的SIRI轨迹组中的个人患CAS进展的风险增加了1.166倍 (95%CI为1.021-1.333).
- 增加的初始SIRI和高度稳定的轨迹都与增加的CAS进展风险相关.
结论:
- 升高的初始SIRI和高度稳定的SIRI轨迹是CAS进展的重要风险因素.
- 监测SIRI趋势可以帮助识别为主动心血管护理的高风险个体.
- 这项研究强调了SIRI在完善动脉样硬化风险分层方面的潜力.
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