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在磁共振引导加速器中进行中断放射治疗的单一机构经验

José Alejandro Rojas-López^1,2, Efraín Martínez-Ortiz³

¹Department of Physics, Faculty of Astronomy, Mathematics, Physics and Computing, National University of Cordoba, Cordoba, Argentina.

Journal of medical physics

|October 30, 2025

概括

低分化成功地管理了MR-linac治疗中断,保持了瘤学结果和患者安全. 这种适应性放射治疗策略确保了治疗的连续性,而不会影响疗效或增加毒性.

科学领域:

辐射瘤学辐射瘤学
医学物理医学物理

背景情况:

一个磁共振引导的线性加速器 (MR-linac) 在2024年7月经历了一次重大故障.
这一事件导致四名接受放射治疗的患者的治疗中断2周.

研究的目的:

为了评估治疗中断后的临床结果和毒性.
评估剂量补偿策略在治疗后长达6个月的影响.

主要方法:

按照皇家放射科医师学院的指导方针进行了低分离治疗.
每个分数的剂量和分数的数量使用线性二次模型进行了重新计算,用于剂量补偿.

主要成果:

尽管中断,但适应剂量对治疗后6个月的瘤结果的影响很小.
所有患者都充分容忍毒性,没有观察到疾病进展.
两名患者实现了完全响应,两名患者实现了部分响应.

结论:

低分离是适应性放射治疗中MR-linac治疗中断的可行策略.
这种方法确保了治疗的连续性,安全性和有效性.
生物剂量适应策略维持了瘤控制,并将毒性降到最低.

关键词:

适应性辐射疗法适应性辐射疗法剂量补偿剂量补偿剂量补偿剂量有效的生物剂量.磁共振引导的线性加速器是指导磁共振的线性加速器.

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