在老年男性中,长期暴露于和主要不良心血管事件之间的关联
Paul J Connelly1, Samuel Owusu Achiaw2, Jocelyn M Friday2
1Department of Endocrinology & Diabetes, Queen Elizabeth University Hospital, Glasgow G51 4TF, UK.
Journal of the Endocrine Society
|October 30, 2025
概括
老年男性的长期丸激素治疗与55%更高的重大心血管不良事件风险有关. 这项研究强调,需要对丸激素替代疗法的心血管安全性进行更多研究.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
背景情况:
- 阴性腺症在老年男性中很常见,并且与不良的心脏代谢结果有关.
- 关于激素治疗的心血管安全问题可能会影响临床决策.
- 丸激素疗法是一种潜在的治疗老年男性的阴性腺体缺陷症.
研究的目的:
- 调查长期丸激素治疗与主要心血管不良事件 (MACE) 之间的关联.
- 评估51岁及以上接受丸激素治疗的男性的心血管风险.
主要方法:
- 使用链接的国家卫生服务数据的回顾性队列研究.
- 包括从2012年起51岁以上的男性,他们的丸激素暴露在2012-2016年期间的处方中.
- 在2017-2022年跟踪参与者,分析使用考克斯模型的时间到第一个MACE (心肌梗塞,不稳定性胸痛,中风,心力衰竭,心血管死亡).
主要成果:
- 这项研究包括440名暴露于的男性和136,051名未暴露的男性.
- 在未经调整的分析中,的暴露与MACE风险增加54%有关 (HR: 1.54).
- 在对混因素进行调整后,丸激素暴露显示MACE风险增加了55% (HR:1.55).
结论:
- 在这个现实世界队列中,长期的丸激素治疗与心血管风险增加有关.
- 现有的试验提供了关于短期到中期安全性的数据.
- 需要进一步的长期数据才能充分理解激素治疗对心血管的影响.
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