红肉,功能,种族以及循环酸盐的其他预测因素
Samantha Sonoda1, Edward Giovannucci2, Kelly Hagadorn3
1Cincinnati Children's Hospital, Cincinnati, USA.
概括
摄入未经加工的红肉与循环中的酸盐相反. 这种关系在功能下降的个体和患有前列腺癌的男性中更为强烈,突出了复杂的饮食和健康相互作用.
科学领域:
- 营养流行病学 营养流行病学
- 心血管健康 心血管健康
- 脏生理学 脏生理学
背景情况:
- 循环中的酸盐与各种健康结果有关,无论是积极的还是消极的.
- 了解饮食和生活方式因素与酸盐的相互作用,对于破译它们在疾病中的作用至关重要.
研究的目的:
- 研究红肉消费,功能,种族,性别和其他生活方式因素与循环酸盐之间的关联.
- 分析与这些因素相关的血和尿酸盐水平.
主要方法:
- 对来自国家健康和营养检查调查 (NHANES) 的5,058名成年人和来自卫生专业人员随访研究 (HPFS) 的1,260名男性进行横截面分析.
- 在NHANES中测量尿酸盐,在HPFS中测量血酸盐.
主要成果:
- 在未经加工的红肉摄入量和循环中的酸盐 (p < 0.001) 之间观察到一个反向关联.
- 这种反向关联在功能下降的个体和后来患上前列腺癌的男性中更为明显.
- 非洲裔美国人在尿液中酸盐含量最低. 发现了与女性性别,估计的膜过率,年龄,体力活动和吸烟的积极关联. 观察到的不良关联是尿中的白蛋白/肌素比率,体重指数和糖尿病 (所有p <0.05).
结论:
- 红肉,降低功能和循环酸盐之间发现了新的关联.
- 证实了生活方式因素与循环酸盐之间的先前报告的关联.
- 研究结果提供了对潜在混因素的见解,产生了假设,并为个性化的营养策略提供了信息.
相关概念视频
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
511
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
511
Serum Studies: Renal Function Tests
336
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
336
Nitric Oxide Signaling Pathway
6.1K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
6.1K
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
158
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
158
Factors Affecting Renal Clearance: Renal Impairment
394
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
394
Antianginal Drugs: Nitrates and β-Blockers
1.3K
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
1.3K


