阻塞性睡眠呼吸暂停和前列腺癌之间的关联:NHANES和门德尔随机化研究
Ying Liu1,2, Binglei Jiang3, Long Xia2
1Department of Transfusion, Zigong First People's Hospital, Zigong, Sichuan, People's Republic of China.
Nature and science of sleep
|October 30, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 显示没有与前列腺癌的总体联系. 然而,在年轻男性中发现了负面关联,这表明需要进一步研究的年龄特异性影响.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 睡眠医学 睡眠医学
- 在瘤学瘤学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一个普遍的全球性疾病.
- 前列腺癌是男性中最常见的癌症.
- OSA与前列腺癌风险之间的关系尚未得到充分证实.
研究的目的:
- 为了研究阻塞性睡眠呼吸暂停和前列腺癌之间的关联.
- 探索OSA和前列腺癌之间潜在的特定年龄关系.
- 为了确定OSA是否因果关系影响前列腺癌风险.
主要方法:
- 在NHANES数据上进行了多变量回归分析.
- 进行了年龄分层分析,以检查不同的年龄组.
- 门德尔的随机化被用来评估因果关系.
主要成果:
- 整体多变量回归显示OSA和前列腺癌之间没有显著的关联 (OR = 0.83;95% CI:0.46-1.48).
- 年龄分层分析显示,在60岁以下的男性中存在显著的负相关性 (OR = 0.07;95% CI:0.01-0.74).
- 在60岁及以上的男性中没有观察到显著的关联 (OR = 1.01;95% CI:0.69-1.49).
- 门德尔随机化没有支持OSA和前列腺癌之间的因果关系 (OR = 0.992;95% CI:0.876-1.124).
结论:
- 没有发现OSA和前列腺癌之间的总体关联.
- 在年轻男性 (<60岁) 中观察到OSA和前列腺癌之间的显著负相关性.
- 需要进一步的研究来阐明潜在的生物机制并确认发现.
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