在选择性脑动脉瘤手术中对脂质体布皮瓦卡因使用的评估
Brandon Laing1, Randall W Treffy1, Cayla Jannsen1
1Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Neurosurgery practice
|October 30, 2025
概括
脂质组布皮瓦卡因 (LB) 没有显著改善术后疼痛控制或减少部手术患者的住院时间. 然而,LB显著增加了整体的止痛药费用.
科学领域:
- 神经外科 神经外科
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 脂质体布皮瓦卡因 (LB) 提供长时间的术后止痛,长达72小时.
- LB已被批准用于局部伤口透,并且通常用于脊柱手术.
- 对于LB在部外科手术术术后护理中的有效性的证据有限.
研究的目的:
- 评估脂质体布皮瓦卡因对接受选择性骨切割的患者手术后护理的影响.
- 为了比较接受LB和未接受LB的患者之间的疼痛评分,停留时间和阿片类药物的使用.
主要方法:
- 79名患者的回顾性评估,这些患者因未破裂的前部循环动脉瘤而接受了选择性切除术.
- 44名患者接受了脂质体布皮瓦卡因 (LB),而35名患者没有 (对照组).
- 分析术后疼痛得分,停留时间 (LOS),阿片类药物使用和止痛药费用.
主要成果:
- 在初始或平均疼痛得分,阿片类药物使用或ICU/整体LOS中,在LB和对照组之间没有发现显著差异.
- 与对照组相比,LB组的止痛药总成本显著更高 ($ 647.84 ± 122.50) 和对照组 ($ 284.77 ± 113.44;P < .0001).
结论:
- 脂质体布皮瓦卡因似乎没有显著影响头骨外科手术患者的疼痛评分,阿片类药物消耗或停留时间.
- 腰包使用与总疼痛药费用的大幅增加有关.
- 需要进一步的前性随机研究来充分评估LB在部外科手术中的好处.
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