阻塞性睡眠呼吸暂停作为感染SARS-CoV-2的患者肺炎的危险因素:一种倾向性得分匹配分析
Yanmei Cao1,2, Yiming Zhao2, Xinghua Shen3
1School of Public Health, Suzhou Medical College of Soochow University, Suzhou, CHN.
Cureus
|October 30, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 在COVID-19患者中很常见,并且独立地增加患肺炎的风险. 在CT扫描上,OSA患者的肺炎更严重,夜间氧气低血症更严重.
科学领域:
- 肺部医学 肺部医学
- 睡眠医学 睡眠医学
- 传染性疾病 传染性疾病
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 和COVID-19共享的病理生理特征,如低氧化和炎症.
- 对于COVID-19肺炎的OSA独立风险尚未得到充分确立.
研究的目的:
- 评估OSA与SARS-CoV-2感染患者COVID-19肺炎风险之间的关联.
主要方法:
- 一个单一的中心,对136名住院的COVID-19患者进行横截面研究.
- 通过家庭睡眠呼吸暂停测试 (HSAT) 诊断的OSA;用于分析的倾向性得分匹配 (PSM).
- 多变量后勤回归确定了COVID-19肺炎的独立风险因素.
主要成果:
- 在SARS-CoV-2感染患者中,OSA患病率为36.76%.
- 在PSM之后,OSA患者的肺炎相关CT异常发生率明显更高.
- OSA患者表现出更严重的夜间低氧化症 (增加ODI,增加TST90).
结论:
- OSA独立地与COVID-19肺炎的风险增加有关.
- 在COVID-19患者中,OSA是肺炎严重程度的重要危险因素.
- 患有OSA的患者体验到更糟糕的放射性结果和与睡眠有关的呼吸系统参数.
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