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局部发达状头癌患者的新辅助化疗免疫疗法:一项回顾性研究

Qiu-Yi Huang¹, Ling-Feng Xu¹, Yuan Wu²

¹Department of Head and Neck Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in oncology

|October 30, 2025

概括

新辅助化疗免疫疗法对局部发达的头部和部状细胞癌 (HNSCC) 是有前途的. 这种治疗改善了病理反应和存活率,并具有可控的副作用.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
头部和部癌症头部和部癌症

背景情况:

对于局部发达的头支状细胞癌 (HNSCC) 的传统治疗方法缺乏足够的生存率改善.
瘤的侵入性和转移有助于HNSCC的复发.
新辅助化学免疫治疗是一种正在发展中的策略,显示出增强的病理反应和生存率.

研究的目的:

追溯分析新辅助化疗免疫治疗在局部发达HNSCC的安全性和有效性.
评估病理反应,生存结果和不良事件.

主要方法:

对82名HNSCC患者的回顾性分析,这些患者接受了新辅助化疗免疫疗法,随后进行了手术.
从2019年1月到2024年5月收集的数据.
评估病理反应,客观反应率 (ORR),病理完整反应 (pCR),主要病理反应 (MPR),R0切除,生存率和不良事件.

主要成果:

高R0切除率 (95.1%) 和客观反应率 (ORR) (79.3%).
病理完整反应 (pCR) 率为25.6%,主要病理反应 (MPR) 率为41.5%.
良好的1年无病存活率 (80.5%) 和整体存活率 (93.7%) 与良好的治疗耐受率 (14.6%的3/4级不良事件).

结论:

新辅助化疗免疫疗法显著改善了局部发达HNSCC的病理反应和R0切除率.
治疗表明不良事件的发生率很低.
新辅助化疗免疫疗法显示出作为局部发达HNSCC的有效治疗策略的潜力.

关键词:

化疗化疗是一种化学疗法.头部和部状细胞癌瘤免疫疗法免疫疗法新辅助疗法是一种新辅助疗法.病理反应是一种病理反应.

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