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关于S100蛋白在肺部疾病中的临床影响的综述
Vineesh V Raveendran1, Somaya AlQattan1, Eid AlMutairy1
1Lung Health Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Frontiers in medicine
|October 30, 2025
概括
在喘和COPD等肺部疾病中,S100蛋白质是关键. 它们显示出作为呼吸系统疾病的生物标志物和治疗点的潜力,但需要进一步研究临床用途.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- S100蛋白质与众多肺部疾病的发病有关,包括喘,COPD,囊性纤维化,PAH,肺纤维化,肺癌,ALI,ARDS,COVID-19和肺移植.
- 它们的正常功能至关重要,因为S100A3和S100A13中的突变与早期发作的肺纤维化有关.
- S100蛋白质作为损伤相关分子模式 (DAMP),通过TLR4和RAGE激活免疫路径,促进炎症和免疫细胞招募.
研究的目的:
- 综合审查S100蛋白在肺部疾病发病过程中的作用.
- 探索它们作为诊断和预后生物标志物以及呼吸系统医学中的治疗点的潜力.
- 讨论S100A蛋白质介导的分子机制在肺炎,重塑,纤维化和瘤发生.
主要方法:
- 这是对肺部疾病中S100蛋白质的现有文献进行叙事性审查.
- 专注于分子机制,生物标志物潜力和治疗向.
- 包括在长期COVID和肺移植等特定条件下S100蛋白质作用的讨论.
主要成果:
- 通过影响炎症,呼吸道重塑,纤维化和瘤发生,S100蛋白质显著促进肺部疾病的进展.
- 在长期COVID等条件下观察到S100水平升高,并作为肺移植排斥的早期生物标志物 (S100A8,S100A9,S100A12).
- S100蛋白调解免疫反应,并影响移植结果.
结论:
- 在呼吸系统医学中,S100蛋白质代表了诊断/预后和治疗的双重潜在目标.
- 临床应用面临挑战,包括疾病特异性变异性和需要强有力的验证.
- 进一步的有针对性的研究和临床试验对于克服局限性并实现S100蛋白质的全部临床潜力至关重要.
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