新型炎症标志物及其与高甘油三血症相关的急性胰腺炎的严重程度的关联
Lin Zhong1,2, Jiezhu Ding3, Manqin Chen2
1Department of Gastroenterology, Shantou University Medical College, Shantou, Guangdong, People's Republic of China.
Journal of inflammation research
|October 30, 2025
概括
新的炎症生物标志物,包括中性粒细胞与高密度脂蛋白胆固醇比率 (NHR),与高甘油三血症相关的急性胰腺炎 (HTG-AP) 严重程度有关. 对于中度至重度的结果,NHR显示出最强的预测值.
科学领域:
- 生物标志物和疾病预测
- 胃肠病学 胃肠病学
- 炎症和免疫学 炎症和免疫学
背景情况:
- 过高甘油血症相关的急性胰腺炎 (HTG-AP) 带来了重大的临床挑战.
- 准确的风险分层对于管理HTG-AP严重程度至关重要.
- 新的炎症生物标志物可能提供更好的预后效用.
研究的目的:
- 调查新型炎症生物标志物与HTG-AP疾病严重程度之间的关联.
- 评估这些生物标志物对风险分层的预后效用.
主要方法:
- 340名HTG-AP患者的回顾性队列研究.
- 各种炎症指数的计算:NHR,MHR,LHR,PHR,SII,SIRI,AISI. 这些指数包括:
- 多变量后勤回归和ROC分析用于预测性绩效评估.
主要成果:
- NHR,SII,SIRI,MHR和AISI显著增加,HTG-AP的严重程度 (P <0.01) 也显著增加.
- NHR与中度至重度的HTG-AP (OR=6.03最高三位数) 有着强烈的独立关联.
- NHR是MSAP+SAP (AUC=0.701) 的最佳预测指标,表现优于其他指数.
结论:
- 中性蛋白与高密度脂蛋白胆固醇比率 (NHR) 是一种中度至重度HTG-AP的独立预测器.
- 对于HTG-AP,NHR有助于早期风险分层.
- SII,MHR,SIRI和AISI提供了互补的预后价值.
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