衰老和活动模式:来自NHANES研究的动图证据.
Wen Luo1, Matthew T Scharf2, Ioannis P Androulakis1
1Biomedical Engineering Department, Rutgers University, New Brunswick, NJ, United States.
Frontiers in systems biology
|October 30, 2025
概括
随着年龄的增长,人们的睡眠-觉醒周期和活动模式发生变化,老年人表现出更有结构的时间表,年轻人睡眠时间较晚. 这些变化凸显了对整个生命周期的个性化健康策略的需求.
科学领域:
- 时间生物学和睡眠科学
- 老年学和衰老研究研究.
- 系统生物学和网络动力学
背景情况:
- 活动模式和睡眠-清醒周期经历了与年龄相关的重大变化.
- 了解这些转变对于开发针对健康衰老的有针对性的干预措施至关重要.
- 动图提供了一种有价值的工具,用于在整个生命周期内表型化休息活动行为.
研究的目的:
- 通过使用国家健康和营养检查调查 (NHANES) 的动图数据,检查与年龄相关的活动模式的变化.
- 使用机器学习识别不同的,年龄相关的休息活动表型.
- 为了发现与衰老相关的时间型和身体参与的变化.
主要方法:
- 从NHANES (2011-2013) 分析了四个年龄组的动图数据.
- 无监督机器学习的应用,以集群平均日休息活动概况.
- 导出关键指标,如取消活动和警觉时间等.
主要成果:
- 年轻人表现出延迟的时间类型,睡眠/觉醒时间较晚;老年人表现出先进的,结构化的时间表.
- 随着年龄的增长,淘汰期也随着年龄的增长而延长,整体活动水平逐渐下降.
- 随着年龄的增长,警觉时间与觉醒时间的相关性减弱,表明生理节律的影响减少.
结论:
- 衰老与睡眠-清醒周期和活动模式的显著转变有关,反映了生物和行为适应.
- 动图学衍生的"动态表型"为系统级睡眠-清醒调节模型提供了洞察力.
- 研究结果支持个性化的干预措施,使睡眠和活动在一生中保持一致,为公众健康和临床老龄化方法提供信息.
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