具有或没有代谢综合征的过:对心血管事件,衰竭和死亡率的差异影响
Yu Ho Lee1, Dae Kyu Kim1, Jin Sug Kim1
1Division of Nephrology, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Republic of Korea.
Frontiers in nutrition
|October 30, 2025
概括
过 (RHF) 和代谢综合征 (MetS) 显著增加心血管事件,病和死亡的风险. 它们的联合存在构成了最大的危险,表明了协同作用的相互作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 代谢疾病 代谢疾病
背景情况:
- 过 (RHF) 和代谢综合征 (MetS) 具有共同的潜在机制,并与健康状况不佳有关.
- 尚不清楚RHF和MetS对临床结果的综合影响.
研究的目的:
- 调查RHF和MetS对心血管事件,末期病 (ESKD) 进展和全因死亡率的综合影响.
- 确定RHF和MetS是否有协同作用,增加健康风险.
主要方法:
- 利用韩国国家医疗保险服务数据库 (2009-2011) 中的278,552个人的数据.
- 员工倾向得分匹配,以创建可比的组.
- 根据RHF和MetS状态对参与者进行分类,以评估心血管事件,ESKD和死亡率的风险.
主要成果:
- 代谢综合征与正常脏过 (NRF) 增加了心血管事件的风险,进一步放大了RHF (HR=1.44).
- 在患有MetS和RHF (HR=3.23) 的人群中,ESKD进展的风险最高.
- 在单独患有RHF或MetS的个体中,全因死亡风险较高,当两种情况都存在时最高 (HR=1.41).
结论:
- RHF的临床意义受代谢综合征状态的影响.
- 随着RHF和MetS的共存,心血管事件,ESKD进展和全因死亡率的风险最高.
- 在心血管事件风险方面观察到RHF和MetS之间的协同相互作用.
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