在GDM A1与健康怀孕中的胰岛素抵抗:使用METS-IR和TyG指数进行比较研究
Hao Jiang1, Min Shang1, Songkun Gao2
1Department of Gynecology and Obstetrics, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.
International journal of women's health
|October 30, 2025
概括
与健康个体相比,孕期糖尿病A1 (GDM A1) 的妇女在整个怀孕期间表现出更高的胰岛素抵抗. 虽然早期的胰岛素抵抗标记与GDM A1诊断有关,但BMI变化会影响其可靠性.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 孕期糖尿病 (GDM) 是一种常见的妊娠并发症.
- 在怀孕期间准确评估胰岛素耐药性对于了解GDM病理生理学及其对结果的影响至关重要.
- 胰岛素抵抗现有的标志物可能会受到怀孕期间生理变化的影响,例如体重指数 (BMI) 的波动.
研究的目的:
- 使用METS-IR和TyG指数,比较患有GDM A1的女性和健康的孕妇之间的整个怀孕胰岛素抵抗水平.
- 评估胰岛素抵抗对怀孕结果的影响.
- 评估BMI增加对胰岛素抵抗指数和GDM A1.1之间的关系的调解效应.
主要方法:
- 根据75克口服葡萄糖耐受性测试 (OGTT) 将344名分娩者分为GDM A1 (n=118) 或正常组.
- 使用BMI,禁食血葡萄糖,甘油三和高密度脂蛋白胆固醇在怀孕早期,中期和晚期的测量,计算了METS-IR和TyG指数值.
- 这些指标的纵向变化和早期怀孕值在各组之间进行了比较,并分析了它们与产科结果的关联. 进行了调解分析,以检查BMI增加的作用.
主要成果:
- 根据METS-IR的指示,与对照组相比,在怀孕中期和晚期的GDM A1组中,胰岛素耐药性明显高于对照组.
- 泰格指数显示,从怀孕早期开始,出现了类似的趋势.
- 虽然早期METS-IR和TyG值与GDM A1诊断有关,但它们与分娩方式,新生儿出生体重或胎盘体重没有显著联系. 体重指数的增加对METS-IR的升高产生了更大的调节效应,而不是对TyG的增加.
结论:
- 与健康对照组相比,患有GDM A1的女性在整个怀孕期间表现出较高的胰岛素抵抗.
- 怀孕早期的METS-IR和TyG指数与GDM A1诊断相关,但与特定的分娩或胎儿参数无关.
- 怀孕期间的BMI变化的影响表明,METS-IR可能不是这个人群中胰岛素耐药性的始终可靠的标志物.
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