一项研究评估心血管疾病和牙周炎之间的关系
Pooja Arora1, Shinu Singla2, B Radhika3
1Department of Dentistry (Periodontology), Advanced Cancer Institute, Bathinda, Punjab, India.
Journal of pharmacy & bioallied sciences
|October 30, 2025
概括
牙周炎通过系统性炎症与心血管疾病 (CVD) 有关. 这项研究发现严重的牙周病与较高的炎症标志物和心血管疾病指标相关.
科学领域:
- 口腔健康和全身疾病
- 心血管健康 心血管健康
- 炎症条件 炎症条件
背景情况:
- 牙周炎和心血管疾病 (CVD) 被认为是慢性炎症疾病.
- 新出现的证据表明,牙周炎和心血管疾病之间存在潜在的病因联系.
研究的目的:
- 调查牙周炎和心血管疾病之间的关联.
- 评估与心脏病相关的临床牙周参数和全身炎症标志物.
主要方法:
- 一项横截面观察性研究包括90名患者 (35-70岁),分为三个组:带有心血管疾病的牙周炎,仅有牙周炎和仅有心血管疾病.
- 记录的关键牙周指标是探针口袋深度 (PPD),临床附着损失 (CAL),斑块指数 (PI) 和探针出血 (BOP).
- 评估了系统性炎症标记物,如C-反应蛋白 (CRP) 和干白素-6 (IL-6).
主要成果:
- 患有牙周炎和心血管疾病的患者表现出最严重的牙周病 (PPD:5.2±1.1毫米;CAL:4.8±0.9毫米) 和炎症标志物升高 (CRP:5.8毫克/升;IL-6:12.5毫克/毫升).
- 观察到CAL和CRP (r=0.62,P=0.001),PPD和静脉血压 (r=0.47,P=0.003),BOP和IL-6 (r=0.51,P=0.002) 之间存在显著的相关性.
- 牙周炎与心血管疾病组显示口腔卫生状况较差,冠状动脉疾病 (CAD) 患病率较高,达到80%.
结论:
- 牙周炎与心血管疾病有显著的关联.
- 系统性炎症似乎是这种关系中介的主要机制.
- 研究结果强调了管理牙周健康对于预防心血管疾病的重要性.
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