氧胺:旧葡萄酒在一个新鲜的新瓶子-服氧胺的野蛮的一面
R Benedict Raj1, Srinath Reddy Narahari1, Vasudev Vemala1
1Department of Paediatric Cardiology and Cardiac Surgery, Children's Heart Institute, Aster Ramesh Hospitals, Vijayawada, Andhra Pradesh, India.
氧胺 (PBZ) 为儿科心脏手术提供了一种安全且具有成本效益的血管策略,特别是在资源有限的环境中. 这种方法可以确保稳定的 perfusion 和良好的结果,即使有有限的新药.
科学领域:
- 心血管外科心血管外科
- 儿科麻醉学 儿科麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 氧胺 (PBZ) 是一种α阻断剂,以前在儿科心脏手术中使用过,但由于低血压问题而停止使用.
- 在资源有限的环境中,PBZ在受控协议下可能是一个可行的,具有成本效益的选择.
研究的目的:
- 评估在儿科开放心脏手术中心肺旁路术期间基于PBZ的血管战略的安全性和有效性.
- 评估PBZ在这个特定患者群体中作为主要血管扩张剂的作用.
主要方法:
- 一项前性观察性研究,涉及520名从2015年到2020年接受心肺旁路 (CPB) 开放心脏手术的儿科患者.
- 作为主要的血管扩张剂,PBZ与低剂量的上腺素相结合.
- 分析了血液动力学数据,ICU结果和术后并发症.
主要成果:
- 通过PBZ协议,在不需要额外的血管压缩剂的情况下保持稳定的手术内 perfusion.
- 大多数患者在同一天被抽管,肺动脉高血压危机发生率微不足道 (1例).
- 死亡率很低 (2.7%),术后低血压可以用液体和上腺素来控制.
结论:
- 使用Phenoxybenzamine (PBZ) 的结构化内科手术方案是儿科心脏手术的安全,经济和有效策略.
- 这种方法在获得新型血管剂的机会有限的环境中尤为有益.
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