在Odontogenic瘤中PCNA和MCM2:一个免疫组织学研究
Sarat K Nayak1, Mitali Dash2, Anshuman Shetty3
1Department of Oral and Maxillofacial Pathology and Microbiology, S. C. B. Dental College, Cuttack, Odisha, India.
Journal of pharmacy & bioallied sciences
|October 30, 2025
概括
增殖细胞核抗原 (PCNA) 和小染色体维护蛋白2 (MCM2) 在乳腺母细胞瘤中显著过度表达,相比于角囊性口腔瘤 (KCOTs). MCM2水平与瘤的侵入性相关,表明其预后潜力.
科学领域:
- 口腔病理学 口腔病理学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 牙发育性瘤表现出可变的增殖潜力,影响其行为.
- 增殖细胞核抗原 (PCNA) 是DNA复制的关键.
- 迷你染色体维护蛋白2 (MCM2) 调节细胞增殖和S相进展.
研究的目的:
- 为了评估PCNA和MCM2表达在牙致癌瘤.
- 为了特别比较乳腺母细胞瘤和囊瘤瘤 (KCOTs) 的表达.
主要方法:
- 免疫组织化学染色被用于分析PCNA和MCM2表达.
- 检查了来自乳腺母细胞瘤和KCOT的组织样本.
主要成果:
- PCNA和MCM2在乳腺母细胞瘤中的过度表达明显高于KCOT.
- 增加的MCM2表达与增加的局部瘤侵入性相关 (P <0.05).
结论:
- 在乳腺母细胞瘤中观察到高MCM2表达.
- MCM2可以作为侵略性乳腺母细胞瘤的预后标志物.
更多相关视频
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
10.2K
07:00Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
6.2K
相关概念视频
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...