后COVID-19并发症:长期COVID症状及其病理生理学的研究
Priyanka Sekar1, Melvin Dominic2, Sudhiersharan Balakrishnan2
1Department of General Medicine, Pondicherry Institute of Medical Sciences, Pondicherry University, Pondicherry, Tamil Nadu, India.
Journal of pharmacy & bioallied sciences
|October 30, 2025
概括
长期COVID在许多康复的患者中会导致疲劳和喘息等持续症状. 免疫系统功能障碍和炎症是其发展的关键因素.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 长期COVID被定义为急性COVID-19感染后持续的症状.
- 这些持续的症状会影响多个器官系统,并显著降低生活质量.
研究的目的:
- 为了确定长期COVID症状的流行率和模式.
- 研究长期COVID背后潜在的病理生理机制.
主要方法:
- 一项为期12个月的横截面研究涉及210名成年COVID-19幸存者 (感染后≥12周).
- 方法包括临床评估,实验室测试和成像,以确定症状和探索机制.
主要成果:
- 观察到疲劳 (67.6%),呼吸困难 (42.8%),认知问题 (39.5%) 和肌痛 (34.7%) 的高患病率.
- 神经精神病的病情影响了41%,29%的人表现出心肺病情.
- 炎症标志物升高与持续症状显著相关 (P<0.05).
结论:
- 长期COVID呈现出广泛的症状,特别是疲劳和神经呼吸系统问题.
- 有证据表明,免疫失调和全身炎症是长期COVID病理生理学的核心.
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