佩格菲尔格拉斯蒂姆 (Neulasta) 诱导的急性风炎:一个病例报告
Pranay Marlecha1, Samir Kapadia1, Akiva Rosenzveig1
1Sections of Clinical Cardiology and Vascular Medicine Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland Clinic, Desk J3-5 9500 Euclid Avenue, Cleveland, OH 44195, USA.
European heart journal. Case reports
|October 30, 2025
概括
颗粒细胞殖民地刺激因子 (G-CSF) 很少会导致急性主动脉炎,这是一个严重的疾病. 早期诊断使用PET/CT扫描和多学科管理对于接受G-CSF治疗的患者至关重要.
科学领域:
- 心血管医学 心血管医学
- 瘤科 支持性护理
- 放射学 放射学是一门学科.
背景情况:
- 颗粒细胞殖民地刺激因子 (G-CSF),特别是佩格菲尔格拉斯蒂姆,被广泛用于预防化疗诱导的中性质衰竭.
- 很少情况下,G-CSF会引发大血管血管炎,包括主动脉炎,这会给诊断和管理带来挑战.
研究的目的:
- 报告一种由G-CSF诱导的急性主动脉炎病例.
- 为了强调PET/CT成像在这种罕见的并发症中的诊断效用.
- 强调多学科方法在管理G-CSF诱导的风炎的重要性.
主要方法:
- 一个59岁患有胰腺癌的女性,接受了佩格菲尔格拉斯蒂姆治疗的案例研究.
- 诊断工作包括实验室检查,CT和PET扫描.
- 管理涉及一种保守的,多学科的方法,适合患者的并发症.
主要成果:
- 患者在服用佩格菲尔格拉斯蒂姆后出现了与急性主动脉炎一致的症状.
- PET/CT成像显示出主动脉炎的特征性发现.
- 保守的管理导致了临床改善和炎症标志物的正常化.
结论:
- 由G-CSF诱导的急性炎是一种新兴的临床实体,需要高度怀疑.
- 对PET/CT扫描进行准确的解释对于诊断至关重要.
- 个性化,多学科的管理策略对于最佳的患者结果至关重要.
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