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中脑动脉狭窄闭塞性疾病的低输液相关功能异常

Yinxi Zou¹, Anqi Cheng¹, Qianqian Si^1,2

¹Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Brain communications

|October 30, 2025

概括

单侧中脑动脉狭窄或闭塞 (MCAs/o) 会导致大脑低 perfusion,导致神经处理变化和神经行为功能受损. 这些变化可以使用先进的成像技术来检测和量化.

科学领域:

神经学神经学
神经成像是一种神经成像.
脑血管疾病脑血管疾病

背景情况:

单边无症状中脑动脉狭窄或闭塞 (MCAs/o) 作为研究慢性脑静脉输液不足的模型.
了解低 perfusion 的神经和神经行为后果对于患者管理至关重要.

研究的目的:

在单边MCA/o患者的hypoperfused区域的功能性大脑异常的特征.
评估这些功能变化的神经行为影响.
开发一种可量化的指数,用于检测早期的功能异常.

主要方法:

发现-验证方法使用两个队列的MCAs/o患者和对照.
双边槽板测试 (GPT) 用于神经行为评估.
动脉旋转标签 (ASL) 用于识别低透区域和评估功能连接 (FC).
机器学习模型开发一个低 perfusion 功能异常指数 (HFAi).

主要成果:

在MCAs/o患者中,GPT性能受损.
低化区域表现出区域内同质性和FC的增加,区域外FC的减少.
HFAi准确地检测到MCAs/o患者的早期功能异常 (AUC = 0.978在发现,0.861在验证).
在两个队伍中,HFAi与GPT表现有显著的相关性.

结论:

单边的MCAs/o导致局部神经同步增加和全球功能集成减少,表明孤立的神经处理.
与低 perfusion 相关的功能异常与神经行为缺陷有关.
HFAi提供了一个客观的方法来量化这些异常及其临床相关性.

关键词:

动脉旋转标签的标签大脑的低 perfusion 的情况.认知障碍是一种认知障碍.功能连接性的功能连接性中间大脑动脉狭窄/闭塞

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