部分口服与静脉注射抗生素治疗内心炎,由多学科团队进行管理:一项回顾性队列研究
Sami El-Dalati1, Bennett Collis2, Takaaki Kobayashi1
1Division of Infectious Diseases, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky, USA.
Open forum infectious diseases
|October 30, 2025
概括
传染性内心炎 (IE) 的口服逐步治疗是安全有效的,与静脉注射治疗相当. 这种由多学科团队管理的方法在IE患者中显示了类似的结果.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 传染性内心炎 (IE) 的口服逐步治疗得到了试验的支持,但未得到充分利用,特别是在北美.
- 对IE的多学科团队管理和抗生素策略需要进一步评估.
研究的目的:
- 为了评估IE患者接受静脉注射 (IV) 或部分口服抗生素治疗的结果.
- 为了比较口服逐步治疗的安全性和有效性与专属IV治疗在现实世界中设置.
主要方法:
- 单一中心对236名确定的IE患者进行了回顾性研究.
- 用多变量逻辑回归分析临床和结果数据.
- 仅接受IV治疗的患者和过渡到部分口服治疗的患者之间的结局的比较.
主要成果:
- 在IV和部分口服治疗组之间,90天的复发感染或所有原因的死亡率没有显著差异.
- 在多变量分析中,口服治疗与90天死亡率的增加无关.
- 死亡率的独立预测因素包括老年,急性心力衰竭和早出院.
结论:
- 对IE的部分口服治疗在由多学科团队管理的选定患者中是安全有效的.
- 部分口服治疗的结果与IE的IV治疗结果相似.
- 这些发现与支持IE口服逐步治疗的欧洲指导方针一致.
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