甲状腺癌:病变,临床病理学,诊断和管理
Yu-Dong Li1, Qing-Yao Ye1, Yan-Xing Chen1
1Department of Thyroid Surgery The Tenth Affiliated Hospital Southern Medical University (Dongguan People's Hospital) Dongguan Guangdong China.
MedComm
|October 30, 2025
概括
甲状腺癌发病率正在上升,但超声波和分子分析等诊断方面的进步有助于风险分层. 精准医学提供个性化的护理,以改善结果并减少这种常见的内分泌恶性瘤的过度治疗.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 甲状腺癌是最常见的内分泌恶性瘤,全球发病率不断增加.
- 虽然大多数类型的预后很好,但像甲状腺癌的形性甲状腺癌这样的侵略性亚型会给生存带来重大挑战.
- 过度诊断和过度治疗仍然是关键问题,尽管诊断方面取得了进展.
研究的目的:
- 为提供甲状腺癌发病,分类和诊断的全面审查.
- 探索不断发展的治疗策略,包括积极监测,向治疗和免疫治疗.
- 强调精准医学在个性化甲状腺癌护理中的作用.
主要方法:
- 审查关于甲状腺癌诊断和管理的当前文献.
- 分析高分辨率超声波和细针吸收活检方面的进展.
- 整合分子分析和风险分层系统 (例如,甲状腺成像报告和数据系统).
主要成果:
- 诊断工具已经改变了甲状腺癌的管理,改善了风险分层.
- 精准医学,整合分子数据,可以减少治疗负担,提高结果.
- 区分惰性结节和攻击性亚型对于有效的管理至关重要.
结论:
- 对诊断标准和治疗框架的持续改进至关重要.
- 以分子诊断和常规参数为指导的个性化护理是改善甲状腺癌结果的关键.
- 了解甲状腺癌生物学方面的进展正在推动更有效的治疗策略.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
7.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.1K
The Thyroid Gland
6.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.6K
mTOR Signaling and Cancer Progression
4.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.6K
Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
Barrett Esophagus-II: Clinical Manifestations and Management
760
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
760


