疾病负担和治疗模式在患有上腺炎和并发性关节炎的患者:一个多中心病例对照研究
Patricia Garbayo-Salmons1,2, Alejandro Molina-Leyva3,4, Anna Porta-Vilaró1
1Department of Dermatology, Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain.
International journal of dermatology
|October 30, 2025
概括
患有关节炎的Hidradenitis suppurativa (HS) 患者经历了更大的疾病负担,包括更多的免疫媒介疾病和更低的生活质量. 这些患者也表现出更高的生物疗法利用率,表明需要综合护理方法.
科学领域:
- 皮肤病学和风湿病学
- 临床流行病学 临床流行病学
- 免疫皮肤学 免疫皮肤学
背景情况:
- 已知 hidradenitis suppurativa (HS) 和关节炎的同时发生,但结合的疾病影响和治疗模式尚不清楚.
- 了解同时存在的HS和关节炎的负担对于有效的患者管理和资源分配至关重要.
研究的目的:
- 评估HS患者患有或没有关节炎的疾病负担和治疗策略.
- 确定HS患者队列中关节炎的流行率和亚型.
主要方法:
- 一项多中心,回顾性,病例控制研究,涉及272名成年HS患者 (69名患有关节炎,203名没有).
- 对照组 (仅HS) 与病例 (HS与关节炎) 的匹配:1:3按性别,年龄和HS持续时间.
- 统计分析包括逻辑回归和线性混合效应模型,以调整混因素.
主要成果:
- 患有关节炎的HS患者的炎症性肠道疾病 (OR 9.44) 和牛皮 (OR 2.99) 发生率更高.
- 患有并存疾病的患者报告皮肤病生活质量指数 (DLQI) 得分显著更高,皮肤病诊断次数增加.
- 在HS患者中,关节炎的患病率为1.70%,其中脊椎关节炎是最常见的亚型 (66.6%);在HS患者中,生物治疗的使用率明显高于关节炎 (72.07%vs39.90%).
结论:
- 患有关节炎的HS患者面临着更严重的疾病负担,并增加了对生物制剂等先进疗法的需求.
- 这些发现强调了多学科护理模式的必要性,以同时管理HS和关节炎,并优化医疗保健资源利用率.
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