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循环节律调节和高血压脏病中的免疫场景异质性:全面的分子探索

Yuanyuan Jiao¹, Lili Liu¹, Weifeng Lin¹

¹Department of Nephrology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Chronobiology international

|October 30, 2025

概括

循环节律的破坏与高血压脏病的免疫细胞透的改变有关. 基因CCL5,ATF3和NR4A1可以作为生物标志物用于诊断和潜在的治疗点在HTN.

科学领域:

基因组学和生物信息学
免疫学免疫学免疫学
腎臟病學 (nephrology) 是一種醫學.

背景情况:

高血压性病 (HTN) 是慢性病的主要原因.
昼夜节律 (CR) 在生理过程中起着至关重要的作用,它们的干扰与各种疾病有关.
关于CR和HTN之间的相互作用,特别是关于免疫环境的相互作用,仍然不完全理解.

研究的目的:

为了研究昼夜节律和高血压性病之间的关系.
确定关键的基因,通路和与HTN中CR相关的分子功能.
分析在HTN中CR和免疫格局之间的相关性.

主要方法:

使用共识聚类和机器学习 (GLM,RF,SVM) 对基因表达综合 (GEO) 数据的综合分析.
使用CIBERSORT,ESTIMATE和ssGSEA算法对免疫细胞透的评估.
功能丰富分析 (GO,KEGG) 和药物标预测 (DGIdb).

主要成果:

确定了45个差异表达的CR相关基因,涉及节律过程和TGF-β信号传递等途径.
开发了一个使用CCL5,ATF3和NR4A1的诊断模型,在HTN诊断中表现良好.
在HTN患者中揭示了免疫异质性和与CR相关的基因集群相关的独特免疫细胞透模式.

结论:

循环节律的扰乱与高血压脏病的免疫环境变化有关.
基因CCL5,ATF3和NR4A1显示出作为HTN诊断和治疗策略的生物标志物的潜力.
需要进一步的实验验证,以确认这些CR相关基因在HTN中的功能作用和临床意义.

关键词:

过高血压性脏病的发生.昼夜节律昼夜节律机械学习学习机械学习微观环境是一个微观环境.

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