患有阿诺德-希亚里形的儿科患者的声麻:系统性审查和元分析
Jad Hosri1, Vanessa Helou2, Jonathan Abou Chaar1
1Department of Otolaryngology-Head and Neck Surgery, American University of Beirut Medical Center, Beirut, Lebanon.
概括
声麻 (VFP) 发病时的年龄对于患有阿诺德-奇亚里形 (ACM) 的儿科患者至关重要. 在这些ACM患者中,较年轻的VFP发病与较差的康复和生存结果有关.
科学领域:
- 神经学 神经学
- 儿科医学 儿科医学
- 遗传学 是一个遗传学.
背景情况:
- 阿诺德-奇亚里形 (Arnold-Chiari malformations,简称ACM) 是一种先天性疾病,影响小脑和脑干.
- 声麻 (VFP) 是儿科ACM患者的重大并发症,影响呼吸道和食.
- 了解ACM中VFP结果的风险因素对于患者管理至关重要.
研究的目的:
- 确定和分析影响声麻 (VFP) 结果的风险因素,在被诊断为阿诺德-奇亚里形 (ACM) 的患者中.
- 确定VFP发病年龄与ACM队列内的患者康复和生存率之间的关联.
主要方法:
- 根据2020年PRISMA检查清单进行了系统审查.
- 在多个数据库中对ACM和VFP的研究进行了全面的文献搜索.
- 使用元分析,包括奇平方测试和二进制后勤回归来评估变量关联.
主要成果:
- 该审查包括33项研究,涉及165名儿科患者 (平均年龄15.31个月);基亚里2型占主导地位 (120例).
- 双边VFP发生在103名患者中;常见的治疗方法包括心室关突移 (65.45%) 和后腔解压 (52.12%).
- 在总体和ACM II队列中,在VFP发病年龄和康复/生存率之间发现了显著的关联.
结论:
- 声麻 (VFP) 发病时的年龄是儿科ACM患者的关键预后因素.
- 较年轻的VFP发病年龄与不完全的症状缓解和降低的生存率相关.
- 早期识别VFP及其时间对于优化ACM的结果至关重要.
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