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电子烟和内皮功能――临床前研究的批判性审查

Mariam Bitar¹, Jérémie Pourchez¹, Claire Le Hello^2,3,4

¹Mines Saint-Etienne, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, F-42023 Saint-Etienne, France.

Chemical research in toxicology

|October 30, 2025

概括

电子烟 (e-cigarettes) 通过损害内皮功能,可能会损害心血管健康. 临床前研究表明,电子烟气溶对血管有负面影响,这表明它们并非无害.

科学领域:

心血管科学心血管科学
毒理学毒理学毒理学
内皮细胞生物学内皮细胞生物学

背景情况:

电子烟 (e-cigarettes) 被推销为比传统烟草更安全的替代品.
临床研究表明,电子烟气溶暴露可能会改变内皮功能,这是心血管风险标志物.
在人类中,这些影响背后的精确生物机制尚不清楚.

研究的目的:

综合审查研究电子烟如何诱导内皮功能障碍的临床前研究.
分析电子烟使用对心血管的影响的现有证据.

主要方法:

对53项临床前研究 (体外和体内) 的定性和定量分析.
评估研究局限性和研究结果的一致性.

主要成果:

试验室研究显示了不同的效果:44%的人报告了不良的内皮功能,30%没有效果,26%的结果是混合的.
在体内研究更一致,有96%表明电子烟对内皮功能有负面影响.
机制包括氧化应激和炎症.

结论:

由于潜在的内皮功能障碍,电子烟带来心血管风险.
电子烟在心血管影响方面不应该被认为是无害的.
需要对标准化设计进行进一步的研究,以隔离尼古丁与其他气溶成分的影响.

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