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香烟烟雾恶化SARS-CoV-2感染引起的肺损伤

Rui Chen1,2, Kenrie P Y Hui2,3, John M Nicholls4

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暴露于香烟烟雾 (CS) 恶化了COVID-19的严重程度,因为它增加了病毒易感性和内质网膜 (ER) 压力. 这导致感染SARS-CoV-2的吸烟者肺部损伤和免疫反应更大.

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慢性慢性肺炎是一种慢性慢性肺炎,COPD是一种慢性肺炎.根据COVID-19的情况,在SARS-CoV-2中.香烟吸烟吸烟吸烟吸烟吸烟吸烟吸烟吸烟吸烟吸烟细胞内膜网膜的压力应激

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科学领域:

  • 肺部医学 肺部医学
  • 病毒学 病毒学
  • 毒理学 毒理学 毒理学

背景情况:

  • 由SARS-CoV-2引起的COVID-19是一种全球性流行病.
  • 经常与CS相关的COPD是严重COVID-19的危险因素.
  • 了解吸烟者的宿主病毒相互作用至关重要.

研究的目的:

  • 调查CS暴露对SARS-CoV-2易感性和疾病严重性的影响.
  • 阐明ER压力在CS-加剧的COVID-19肺损伤中的作用.

主要方法:

  • 转基因K18-hACE2小鼠被暴露在CS或假空气中.
  • 随后,小鼠被感染了SARS-CoV-2或模拟病毒.
  • 分析了肺组织的病毒载量,ER压力标志物,免疫反应和组织病理学.

主要成果:

  • CS暴露上调了ACE2和BiP,增加了病毒敏感性.
  • 通过ATF6和PKR通路,CS诱导了ER压力,促进了亡.
  • 之前的CS暴露加剧了SARS-CoV-2引起的上皮损伤,状腺功能障碍和肺纤维化.

结论:

  • 在CS-加剧的SARS-CoV-2肺损伤中,ER压力起着重要作用.
  • 在吸烟者中,CS暴露会恶化COVID-19的病原性.
  • 这些发现表明,在治疗COVID-19的吸烟者方面,有潜在的治疗点.