香烟烟雾恶化SARS-CoV-2感染引起的肺损伤
Rui Chen1,2, Kenrie P Y Hui2,3, John M Nicholls4
1Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Journal of medical virology
|October 30, 2025
概括
暴露于香烟烟雾 (CS) 恶化了COVID-19的严重程度,因为它增加了病毒易感性和内质网膜 (ER) 压力. 这导致感染SARS-CoV-2的吸烟者肺部损伤和免疫反应更大.
科学领域:
- 肺部医学 肺部医学
- 病毒学 病毒学
- 毒理学 毒理学 毒理学
背景情况:
- 由SARS-CoV-2引起的COVID-19是一种全球性流行病.
- 经常与CS相关的COPD是严重COVID-19的危险因素.
- 了解吸烟者的宿主病毒相互作用至关重要.
研究的目的:
- 调查CS暴露对SARS-CoV-2易感性和疾病严重性的影响.
- 阐明ER压力在CS-加剧的COVID-19肺损伤中的作用.
主要方法:
- 转基因K18-hACE2小鼠被暴露在CS或假空气中.
- 随后,小鼠被感染了SARS-CoV-2或模拟病毒.
- 分析了肺组织的病毒载量,ER压力标志物,免疫反应和组织病理学.
主要成果:
- CS暴露上调了ACE2和BiP,增加了病毒敏感性.
- 通过ATF6和PKR通路,CS诱导了ER压力,促进了亡.
- 之前的CS暴露加剧了SARS-CoV-2引起的上皮损伤,状腺功能障碍和肺纤维化.
结论:
- 在CS-加剧的SARS-CoV-2肺损伤中,ER压力起着重要作用.
- 在吸烟者中,CS暴露会恶化COVID-19的病原性.
- 这些发现表明,在治疗COVID-19的吸烟者方面,有潜在的治疗点.
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