始终坚持身体活动指南和消化系统癌症风险和死亡率
Yiwen Zhang1,2, Dong Hoon Lee1,3, Leandro F M Rezende4,5
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
JAMA oncology
|October 30, 2025
概括
几十年来持续满足体力活动指南 (≥7.5代谢等价任务[MET]小时/周) 显著降低了消化系统癌症 (DSC) 的风险. 适度,长期坚持 (大约17个MET小时/周) 提供最佳益处,较高的数量显示没有额外的优势.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 在瘤学瘤学.
背景情况:
- 身体活动与消化系统癌症 (DSC) 风险的降低有关.
- 对于DSC预防的最佳体力活动水平和长期一致性尚不清楚.
研究的目的:
- 调查身体活动水平,一致性,DSC风险和死亡率之间的关联.
- 确定最佳的体力活动量和长期坚持以减少DSC风险.
主要方法:
- 基于人口的队列研究,利用来自美国三大前队列的数据.
- 休时间的体力活动通过两年一次的问卷进行评估 (MET-小时/周);一致性计算为随访年达到指导方针的百分比 (≥7.5 MET-小时/周).
- DSC包括消化道和辅助器官的癌症;随访时间长达32年.
主要成果:
- 较高的体力活动水平与较低的DSC风险和死亡率有关.
- 在传统的剂量反应分析中,建议最佳风险降低为每周~50个MET小时.
- 在过去的30年里,持续达到适度的活动水平 (每周约17个MET小时) 显著降低了DSC风险,而较高的数量 (每周约38.5个MET小时) 没有额外的好处.
结论:
- 身体活动的长期一致性对于最佳的消化系统癌症风险降低至关重要.
- 保持适度的体力活动水平 (每周约17个MET小时) 持续几十年,为预防DSC提供了巨大的好处.
相关概念视频
Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
Lifestyle Factors and Health
393
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
393
Assessment of the Gastrointestinal System II: Health Perception Pattern
427
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
427
Assessment of the Gastrointestinal System I: Subjective Data
590
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
590
Regulation of the Digestive System
2.8K
Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of...
The effectors in this regulation system are glands and smooth muscles. Activation of...
2.8K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
604
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
604


